A fuzzy-based reliaility for JXTA-overlay P2P platform considering data download speed, peer congestion situation, number of interaction and packet loss parameters

(c) 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.In this paper, we propose and evaluate a new fuzzy-based reliability system for Peer-to-Peer (P2P) communications in JXTA-Overlay platform considering as a new parameter the peer congestion situation. In our system, we considered four input parameters: Data Download Speed (DDS), Peer Congestion Situation (PCS), Number of Interactions (NI) and Packet Loss (PL) to decide the Peer Reliability (PR). We evaluate the proposed system by computer simulations. The simulation results have shown that the proposed system has a good performance and can choose reliable peers to connect in JXTA-Overlay platform.Peer ReviewedPostprint (author's final draft

A GA-based simulation system for WMNs: comparison analysis for different number of flows, client distributions, DCF and EDCA functions

In this paper, we compare the performance of Distributed Coordination Function (DCF) and Enhanced Distributed Channel Access (EDCA) for normal and uniform distributions of mesh clients considering two Wireless Mesh Network (WMN) architectures. As evaluation metrics, we consider throughput, delay, jitter and fairness index metrics. For simulations, we used WMN-GA simulation system, ns-3 and Optimized Link State Routing. The simulation results show that for normal distribution, the throughput of I/B WMN is higher than Hybrid WMN architecture. For uniform distribution, in case of I/B WMN, the throughput of EDCA is a little bit higher than Hybrid WMN. However, for Hybrid WMN, the throughput of DCF is higher than EDCA. For normal distribution, the delay and jitter of Hybrid WMN are lower compared with I/B WMN. For uniform distribution, the delay and jitter of both architectures are almost the same. However, in the case of DCF for 20 flows, the delay and jitter of I/B WMN are lower compared with Hybrid WMN. For I/B architecture, in case of normal distribution the fairness index of DCF is higher than EDCA. However, for Hybrid WMN, the fairness index of EDCA is higher than DCF. For uniform distribution, the fairness index of few flows is higher than others for both WMN architectures.Peer ReviewedPostprint (author's final draft

A GA-based simulation system for WMNs: performance analysis for different WMN architectures considering transmission rate and OLRS protocol

(c) 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.In this paper, we evaluate the performance of two WMN architectures considering throughput, delay, jitter and fairness index metrics. For simulations, we used ns-3. We compare the performance for two architectures considering transmission rate and OLSR protocol. The simulation results show that for transmission rate 600 and 1200 [kbps], the throughput of Hybrid WMN is higher than I/B WMN. For transmission rate 600 and 1200 [kbps], the delay and jitter of Hybrid WMN is lower than I/B WMN. For transmission rate 600 and 1200 [kbps], the fairness index of I/B WMN is higher than Hybrid WMN.Peer ReviewedPostprint (author's final draft

Room-Temperature Fluorescence Lifetime of Pseudoisocyanine (PIC) J Excitons with Various Aggregate Morphologies in Relation to Microcavity Polariton Formation

The results of room-temperature fluorescence lifetime measurements are reported for the excitation of J aggregates (Js) of pseudoisocyanine chloride (PIC-Cl) prepared in potassium polyvinyl sulfate (PVS) polymer thin films, their aqueous solutions, and NaCl aqueous solutions. Variations of the microscopic morphologies of the aggregates were investigated. The results show that fluorescence decay features correlated to the morphology change. The observed fluorescence lifetime and quantum efficiency of PIC J aggregates (PIC-Js) in a NaCl aqueous solution were 310 ps and 28%, respectively. The lifetime of the fibril-shaped macroaggregates prepared in PVS thin films was below the instrumental time resolution of 5 ps, and the efficiency decreased to below 3%. The results indicate that PIC-Js prepared with PVS polymers have an increased nonradiative contribution to the excitation deactivation process. In particular, macro-Js with isolated fibril-shaped structures revealed nonradiative pathway(s) that are closely associated to the specific packaging morphology of the constituent meso-Js. The possibility of a destructive effect on the formation of cavity-polaritons is also discussed

A study of using SmartBox to embed emotion awareness through stimulation into e-learning environments

(c) 2014 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.Emotions strongly influence human's behavior in individual and social situations and must be seriously considered in any human activity, such as e-Learning. Indeed, the embedding of emotional awareness features into virtual learning environments could offer a more authentic and challenging e-Learning experience, either individual or collaborative. However, the lack of empirical results together with the complexity attributed to the management by computers of human emotions and affective data, seriously limits the advances in e-Learning as it impedes to virtualize many real-world learning situations in which emotions play a significant role. In this paper, we investigate the use of the SmartBox device for emotion measurement of distance learners during their study as well as the development of affective strategies based on the SmartBox's stimulation capabilities. The aim is to collect emotion data from different sources in order to provide the most appropriate affective responses that positively influence distance learners' study and results and ultimately enhance the e-Learning process.Peer ReviewedPostprint (author's final draft

Design and implementation of testbed using IoT and P2P technologies: improving reliability by a fuzzy-based approach

The internet of things (IoT) is a new type of internet application which enables the objects to be active participants with other members of the network. In P2P systems, each peer has to obtain information of other peers and propagate the information through neighbouring peers. However, in reality, each peer might be faulty or might send incorrect information. In our previous work, we implemented a P2P platform called JXTA-overlay, which provides a set of basic functionalities, primitives, intended to be as complete as possible to satisfy the needs of most JXTA-based applications. In this paper, we present the implementation of a testbed using IoT and P2P technologies. We also present two fuzzy-based systems (FPRS1 and FPRS2) to improve the reliability of the proposed approach. Comparing the complexity of FPRS1 and FPRS2, the FPRS2 is more complex than FPRS1. However, FPRS2 makes the platform more reliable.Peer ReviewedPostprint (author's final draft

Local balance of transforming growth factor-β1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma

金沢大学大学院医学系研究科がん細胞学Tumor-stromal interactions are important for the progression of malignant tumors. The purpose of the present study was to examine interactions of cholangiocarcinoma (CC) cells and stromal fibroblasts with respect to stromal-derived factor-1 (SDF-1) and transforming growth factor (TGF)-β1. Two cell lines of CC (HuCCT-1 and CCKS-1) and WI-38 fibroblast cell line were used for cell culture, and 12 CC tissue specimens for immunohistochemical studies. Invasion of CC cells was increased significantly by the supernatant from fibroblast cultures, but not by the supernatant from fibroblasts cocultured with CC cells. Expression of SDF-1 in cultured fibroblasts was downregulated by TGF-β1 treatment, and coculture with CC cells and anti-TGF-β1 neutralizing antibody restored the decreased SDF-1 expression, suggesting that TGF-β1 secreted from CC cells might have reduced the expression of SDF-1 by fibroblasts and might have reduced the increased invasion of CC cells induced by the supernatant from fibroblasts. Immunohistochemical expression of TGF-β1 in CC cells was focal or negative and that of SDF-1 was evident in stromal fibroblasts at the invasive front of CC. In conclusion, local mutual influence of TGF-β1 secreted from carcinoma cells and SDF-1 expressed by stromal fibroblasts may be involved in invasion of CC cells. © 2006 Japanese Society of Pathology

Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism.

Low body temperature predicts a poor outcome in patients with heart failure, but the underlying pathological mechanisms and implications are largely unknown. Brown adipose tissue (BAT) was initially characterised as a thermogenic organ, and recent studies have suggested it plays a crucial role in maintaining systemic metabolic health. While these reports suggest a potential link between BAT and heart failure, the potential role of BAT dysfunction in heart failure has not been investigated. Here, we demonstrate that alteration of BAT function contributes to development of heart failure through disorientation in choline metabolism. Thoracic aortic constriction (TAC) or myocardial infarction (MI) reduced the thermogenic capacity of BAT in mice, leading to significant reduction of body temperature with cold exposure. BAT became hypoxic with TAC or MI, and hypoxic stress induced apoptosis of brown adipocytes. Enhancement of BAT function improved thermogenesis and cardiac function in TAC mice. Conversely, systolic function was impaired in a mouse model of genetic BAT dysfunction, in association with a low survival rate after TAC. Metabolomic analysis showed that reduced BAT thermogenesis was associated with elevation of plasma trimethylamine N-oxide (TMAO) levels. Administration of TMAO to mice led to significant reduction of phosphocreatine and ATP levels in cardiac tissue via suppression of mitochondrial complex IV activity. Genetic or pharmacological inhibition of flavin-containing monooxygenase reduced the plasma TMAO level in mice, and improved cardiac dysfunction in animals with left ventricular pressure overload. In patients with dilated cardiomyopathy, body temperature was low along with elevation of plasma choline and TMAO levels. These results suggest that maintenance of BAT homeostasis and reducing TMAO production could be potential next-generation therapies for heart failure.We thank Kaori Yoshida, Keiko Uchiyama, Satomi Kawai, Naomi Hatanaka, Yoko Sawaguchi, Runa Washio, Takako Ichihashi, Nanako Koike, Keiko Uchiyama, Masaaki Nameta (Niigata University), Kaori Igarashi, Kaori Saitoh, Keiko Endo, Hiroko Maki, Ayano Ueno, Maki Ohishi, Sanae Yamanaka, Noriko Kagata (Keio University) for their excellent technical assistance, C. Ronald Kahn (Joslin Diabetes Center and Harvard Medical School) for providing the BAT cell line, Evan Rosen (Harvard Medical School) for providing us Ucp-Cre mice, Kosuke Morikawa (Kyoto University), Tomitake Tsukihara (University of Hyogo) and Shinya Yoshikawa (University of Hyogo) for their professional opinions and suggestions. Tis work was supported by a Grant-in-Aid for Scientifc Research (A) (20H00533) from MEXT, AMED under Grant Numbers JP20ek0210114, and AMED-CREST under Grant Number JP20gm1110012, and Moonshot Research and Development Program (21zf0127003s0201), MEXT Supported Program for the Strategic Research Foundation at Private Universities Japan, Private University Research Branding Project, and Leading Initiative for Excellent Young Researchers, and grants from the Takeda Medical Research Foundation, the Vehicle Racing Commemorative Foundation, Ono Medical Research Foundation, and the Suzuken Memorial Foundation (to T.M.). Support was also provided by a Grants-in-Aid for Young Scientists (Start-up) (26893080), and grants from the Uehara Memorial Foundation, Kowa Life Science Foundation, Manpei Suzuki Diabetes Foundation, SENSHIN Medical Research Foundation, ONO Medical Research Foundation, Tsukada Grant for Niigata University Medical Research, Te Nakajima Foundation, SUZUKEN memorial foundation, HOKUTO Corporation, Mochida Memorial Foundation for Medical & Pharmaceutical Research, Grants-in-Aid for Encouragement of Young Scientists (A) (16H06244), Daiichi Sankyo Foundation of Life Science, AMED Project for Elucidating and Controlling Mechanisms of Aging and Longevity under Grant Number JP17gm5010002, JP18gm5010002, JP19gm5010002, JP20gm5010002, JP21gm5010002, Astellas Foundation for Research on Metabolic Disorders, Research grant from Naito Foundation, Te Japan Geriatrics Society (to I.S.); by a Grant-in-Aid for Scientifc Research (C) (19K08974), Yujin Memorial Grant, Sakakibara Memorial Research Grant from Te Japan Research Promotion Society for Cardiovascular Diseases, TERUMO Life Science Foundation, Kanae Foundation (to Y.Y.), JST ERATO (JPMJER1902), AMED-CREST (JP20gm1010009), the Takeda Science Foundation, the Food Science Institute Foundation (to S.F.), and by a grant from Bourbon (to T.M., I.S. and Y.Y.).S

Combination of p53AIP1 and survivin expression is a powerful prognostic marker in non-small cell lung cancer

<p>Abstract</p> <p>Background</p> <p>p53AIP1 is a potential mediator of apoptosis depending on p53, which is mutated in many kinds of carcinoma. High survivin expression in non-small cell lung cancer is related with poor prognosis. To investigate the role of these genes in non-small cell lung cancer, we compared the relationship between p53AIP1 or survivin gene expression and the clinicopathological status of lung cancer.</p> <p>Materials and methods</p> <p>Forty-seven samples from non-small cell lung cancer patients were obtained between 1997 and 2003. For quantitative evaluation of RNA expression by PCR, we used Taqman PCR methods.</p> <p>Results</p> <p>Although no correlation between p53AIP1 or survivin gene expression and clinicopathological factors was found, the relationship between survivin gene expression and nodal status was significant (p = 0.03). Overall survival in the p53AIP1-negative group was significantly worse than in the positive group (p = 0.04); however, although survivin expression was not a prognostic factor, the combination of p53AIP1 and survivin was a significant prognostic predictor (p = 0.04). In the multivariate cox proportional hazard model, the combination was an independent predictor of overall survival (p53AIP1 (+) survivin (+), HR 0.21, 95%CI = [0.01–1.66]; p53AIP1 (+) survivin (-), HR 0.01, 95%CI = [0.002–0.28]; p53AIP1 (-) survivin (-), HR 0.01, 95%CI = [0.002–3.1], against p53AIP1 (-) survivin (+), p = 0.03).</p> <p>Conclusion</p> <p>These data suggest that the combination of p53AIP1 and survivin gene expression may be a powerful tool to stratify subgroups with better or worse prognosis from the variable non-small cell lung cancer population.</p